Pharmacological mechanism in slip-down behavior of mice
| Autor: | Tetsuo Shimizu, Junya Sugawara, Minoru Suzuki, Naxin Guo, Yoshihikio Kawarada, Takaubu Takemura, Yang Liu, Yutaka Masuda, Toshihiro Sugiyama |
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| Rok vydání: | 2003 |
| Předmět: |
Agonist
Male medicine.medical_specialty medicine.drug_class Mice Inbred Strains Pharmacology Motor Activity General Biochemistry Genetics and Molecular Biology Methamphetamine Mice Opioid receptor Internal medicine medicine Animals Receptor Behavior Animal Dose-Response Relationship Drug Chemistry General Medicine Endocrinology Monoamine neurotransmitter Opioid Dopamine Agonists Morphine Dopamine Antagonists μ-opioid receptor medicine.drug |
| Zdroj: | The Tohoku journal of experimental medicine. 201(1) |
| ISSN: | 0040-8727 |
| Popis: | Slip-down from a raised platform was previously found in mice treated with morphine, and this behavior was also recognized in mice treated with a monoamine releaser methamphetamine. Pharmacological examination on the slip-down indicated that the behavior was induced by receptor stimulations by D2 agonist PPHT and 5HT-2 agonist DOI. In mice treated with PPHT, antagonists of D1, alpha2, 5HT-2 and opioid mu and kappa suppressed the behavior. In mice treated with DOI, antagonists of D1, alpha2, 5HT-1A, 5HT-3 and opioid mu and delta suppressed the behavior. These present findings suggest that the slip-down was mainly induced by opioid mu receptor activity regulated with monoamine activities. When the slip-down is considered as an anxious behavior, it may be also suggested that the anxiety induced by 5-HT activities furthermore stimulated the behavior via the other opioid receptor activities. |
| Databáze: | OpenAIRE |
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