Normal pattern of parathyroid response to blood calcium lowering in primary hyperparathyroidism: a citrate clamp study
| Autor: | H. A. Serensen, Peter Schwarz, I. Transbel, Peter McNair, G. Momsen |
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| Rok vydání: | 1992 |
| Předmět: |
Adenoma
Adult Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Parathyroid hormone chemistry.chemical_element Calcium Citric Acid Parathyroid Glands chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Hypocalcaemia Citrates Aged Trisodium citrate Calcium metabolism Hyperparathyroidism Parathyroid chief cell Middle Aged medicine.disease Parathyroid Neoplasms chemistry Parathyroid Hormone Female Primary hyperparathyroidism |
| Zdroj: | Clinical Endocrinology. 37:344-348 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.1992.tb02336.x |
| Popis: | OBJECTIVE The objective of the present study was to elucidate the parathyroid responsiveness by measurements of blood Ionized calcium and serum intact parathyrold hormone (PTH) concentrations, before and during trisodium citrate induced hypocalcaemia. PATIENTS AND CONTROLS Sixteen patients with primary hyperparathyroidism and 32 healthy volunteers. DESIGN Blood ionized calcium concentration was lowered by about 0.20 mmol/l and maintained at this level for 2 hours by blood ionized calcium controlled trisodium citrate infusion. MEASUREMENTS Serum PTH(1–84) was measured by an Immunoradiometric assay. RESULTS In patients and controls, baseline measurements of blood Ionized calcium were 1.39±0.07 vs 1.24±0.04 mmol/l (mean.SD) (P |
| Databáze: | OpenAIRE |
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