Prenatal Sex Hormones and Behavioral Outcomes in Children
| Autor: | Emily S. Barrett, Brent R. Collett, Nicole R. Bush, Christina Wang, Sheela Sathyanarayana, Shanna H. Swan, Drew B. Day, Tides Study team |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Epidemiology Health Toxicology and Mutagenesis Endocrinology Diabetes and Metabolism Neurodevelopment Physiology Child Behavior Reproductive health and childbirth Medical and Health Sciences Cohort Studies chemistry.chemical_compound 0302 clinical medicine Endocrinology Sex hormone-binding globulin Child Development Pregnancy Testosterone Child Gonadal Steroid Hormones Pediatric Psychiatry Global and Planetary Change biology Estradiol TIDES Study team Pollution Psychiatry and Mental health Child Preschool Prenatal Exposure Delayed Effects Female Cohort study Adult Child behavior medicine.drug_class Estrone Basic Behavioral and Social Science Article 03 medical and health sciences Clinical Research Behavioral and Social Science medicine Humans Preschool Biological Psychiatry Problem Behavior Endocrine and Autonomic Systems business.industry Estriol Contraception/Reproduction Psychology and Cognitive Sciences Public Health Environmental and Occupational Health medicine.disease Estrogen 030227 psychiatry Adaptive Skills Composite Score chemistry Neurodevelopmental Disorders biology.protein business 030217 neurology & neurosurgery Hormone |
| Zdroj: | Psychoneuroendocrinology |
| Popis: | Abnormal sex hormone levels in utero have been associated with child behavioral problems, but it is unclear if normal variation in prenatal sex hormones is associated with subsequent behavior in childhood. We assessed maternal sex hormones, including serum estrone (E1), estradiol (E2), estriol (E3), free testosterone (FT), and total testosterone (TT), during early pregnancy (gestational week 6-21 (mean = 11.1)) and evaluated child behavior at ages 4-5 using the Behavioral Assessment System for Children (BASC-2) and Social Responsiveness Scale (SRS-2) in 404 mother/child pairs (211 girls, 193 boys) within The Infant Development and Environment Study, a multi-site pregnancy cohort study. Associations between hormones and composite scores were evaluated using multiple linear regressions in both sexes combined, and separate models assessed effect modification by sex with the addition of interaction terms. A 10-fold increase in maternal FT or TT was associated in both sexes with a 4.3-point (95 % CI: 0.5, 8.2) or 4.4-point (0.8, 8.0) higher BASC-2 internalizing composite T score, respectively. In addition, a 10-fold increase in FT or TT was associated with a 3.8-point (0.04, 7.5) or 4.0-point (0.5, 7.5) higher behavioral symptoms index composite score. In models evaluating effect modification by sex, a 10-fold increase in E1 was associated with a 4.3-point (1.2, 7.4) decrease in adaptive skills composite score in girls only (interaction p = 0.04). We observed associations between testosterone and internalizing behaviors and behavioral symptoms index in both sexes, as well as a female-specific association between E1 and adaptive skills. Sex hormones during pregnancy may play a key role in influencing later-life behavior, and additional studies should further examine different periods of susceptibility to hormonal signals. |
| Databáze: | OpenAIRE |
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