Intra- and extracellular fluorouracil uptake: assessment with contrast-enhanced metabolic F-19 MR imaging
| Autor: | Ludwig Gerlach, Matthias E. Bellemann, Gunnar Brix, Uwe Haberkorn |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Gadolinium DTPA
Male Gadoxetic acid Antimetabolites Antineoplastic Magnetic Resonance Spectroscopy Gadolinium chemistry.chemical_element Contrast Media Liver Neoplasms Experimental medicine Extracellular Distribution (pharmacology) Animals Humans Radiology Nuclear Medicine and imaging Tissue Distribution medicine.diagnostic_test business.industry Phantoms Imaging Magnetic resonance imaging Fluorine Magnetic Resonance Imaging Rats Rats Inbred ACI Contrast medium chemistry Fluorouracil Nuclear medicine business Intracellular Neoplasm Transplantation medicine.drug |
| Zdroj: | Radiology. 209(1) |
| ISSN: | 0033-8419 |
| Popis: | To assess the extra- and intracellular uptake of the anticancer drug fluorouracil and its major catabolite alpha-fluoro-beta-alanine (FBAL) at gadolinium-enhanced fluorine-19 magnetic resonance (MR) imaging.The relative fluorouracil and FBAL F-19 signal intensity increases due to extracellular and hepatobiliary paramagnetic contrast media were evaluated in ACI rats with transplanted Morris hepatoma. Control rats (n = 6) did not receive contrast medium; study rats received gadopentetate dimeglumine (n = 6) or gadoxetic acid (n = 6) before intravenous fluorouracil administration. The biodistributions of fluorouracil and FBAL were mapped at metabolic F-19 MR imaging at about 6 minutes (early distribution phase) and 64 minutes (metabolic phase), respectively, after drug administration.Gadopentetate dimeglumine induced a significant (P.05) increase in the signal intensity of fluorouracil (70%) in the hepatoma; gadoxetic acid induced a significant increase in the signal intensity of fluorouracil in the hepatoma (85%) and of FBAL in the liver (71%). The fluorouracil liver signal intensity did not increase with either contrast medium.Whereas a marked amount of fluorouracil is in the extracellular tumor compartment 6 minutes after fluorouracil administration, the dominant fluorouracil signal intensity in the liver at 6 minutes arises from the intracellular compartment, which can be explained as retention of fluorouracil in hepatocytes. The marked increase in the FBAL signal intensity about 1 hour after fluorouracil administration is congruent with our observation of a high intracellular uptake of gadoxetic acid in the liver at about 1 hour. |
| Databáze: | OpenAIRE |
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