Divergent Pd-catalyzed Functionalization of 4-Oxazolin-2-ones and 4-Methylene-2-oxazolidinones and Synthesis of Heterocyclic-Fused Indoles

Autor:	Daniel Yescas-Galicia, Rodrigo A. Restrepo-Osorio, Ailyn N. García-González, Roberto I. Hernández-Benítez, José C. Espinoza-Hicks, Carlos H. Escalante, Edson Barrera, Blanca M. Santoyo, Francisco Delgado, Joaquín Tamariz
Rok vydání:	2022
Předmět:	Indoles Methanol Organic Chemistry Ellipticines Methane Catalysis Oxazolidinones Palladium
Zdroj:	The Journal of Organic Chemistry. 87:13034-13052
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.2c01563
Popis:	Palladium-catalyzed functionalization was presently performed on two building blocks: 4-oxazolin-2-ones and 4-methylene-2-oxazolidinones. Direct Heck arylation of 4-oxazolin-2-ones led to a series of 5-aryl-4-oxazolin-2-ones, including analogues with N-chiral auxiliary, in an almost quantitative yield. The Pd(II)-catalyzed homocoupling reaction of 4-oxazolin-2-ones provided novel heterocyclic across-ring dienes. Meanwhile, the intramolecular cross-coupling of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c651da48f8559f821cd3daa2168d7b2 https://doi.org/10.1021/acs.joc.2c01563 Zobrazit plný text záznamu