Toxicity and Metabolomic Impact of Cobalt, Chromium, and Nickel Exposure on HepaRG Hepatocytes

Autor:	Marie Bellouard, Marie Gasser, Sébastien Lenglet, Federica Gilardi, Nasim Bararpour, Marc Augsburger, Aurélien Thomas, Jean-Claude Alvarez
Rok vydání:	2022
Předmět:	Chromium Metals Nickel Hepatocytes Humans Cobalt General Medicine Toxicology
Zdroj:	Chemical Research in Toxicology. 35:807-816
ISSN:	1520-5010 0893-228X
Popis:	Cobalt, chromium, and nickel are used in orthopedic prostheses. They can be released, accumulate in many organs, and be toxic. The aim of this study is to evaluate the cytotoxicity of these metals on human hepatocytes and to improve our knowledge of their cellular toxicity mechanisms by metabolomic analysis. HepaRG cells were incubated for 48 h with increasing concentrations of metals to determine their IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6339e65312b8f5b44fa191742dc12a https://doi.org/10.1021/acs.chemrestox.1c00429 Zobrazit plný text záznamu