Intramuscular infiltration of a local anesthetic, lidocaine, does not result in adverse behavioural side effects in rainbow trout
| Autor: | C. M. Creighton, F. Chatigny, E. D. Stevens |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system animal structures Lidocaine 040301 veterinary sciences medicine.drug_class animal diseases medicine.medical_treatment lcsh:Medicine Injections Intramuscular digestive system Article 0403 veterinary science 03 medical and health sciences Animal model Animal science medicine Animals 14. Life underwater Anesthetics Local Muscle Skeletal lcsh:Science Saline Multidisciplinary Behavior Animal biology urogenital system business.industry Local anesthetic lcsh:R 04 agricultural and veterinary sciences Intramuscular infiltration biology.organism_classification medicine.disease 3. Good health Trout 030104 developmental biology Oncorhynchus mykiss lcsh:Q Rainbow trout business Infiltration (medical) medicine.drug |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-28621-5 |
| Popis: | Fish are a useful animal model for research, but our improvement in some aspects of their welfare has not kept pace with their increased popularity for this use. For example, researchers rarely use analgesics. We evaluated the side effects of lidocaine, a local anesthetic widely used in human and veterinary medicine. We infiltrated lidocaine on each side of the dorsal fin (total 20 mg/kg) of young rainbow trout (15 fish per group) compared with infiltration with an equal volume of saline. We monitored behaviour of individual trout during the 4-hour trial. Food was presented 5 times during the trial (30 min, 1 h, 2 h, 3 h, 4 h after infiltration) and we analyzed behaviour for 1 minute before and after food presentation. Behaviour of Saline-Infiltrated trout compared with trout that received no infiltration showed that infiltration in and of itself had no statistically significant effects on trout behaviour. However, there were many statistically significant effects of Lidocaine-Infiltrated trout compared with Saline-Infiltrated trout; none of the side-effects were adverse. |
| Databáze: | OpenAIRE |
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