Photodynamic Therapy of Superficial Basal Cell Carcinomas Using Topical 5-Aminolevulinic Acid in a Nanocolloid Lotion
| Autor: | G. Hänggi, A.F. Hürlimann, R.G. Panizzon |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin Neoplasms Administration Topical Biopsy medicine.medical_treatment Endogeny Photodynamic therapy Dermatology chemistry.chemical_compound polycyclic compounds medicine Humans Basal cell carcinoma Photosensitizer Aged Skin Aged 80 and over Photosensitizing Agents medicine.diagnostic_test Protoporphyrin IX business.industry Aminolevulinic Acid Photosensitizing Agent Middle Aged medicine.disease Treatment Outcome Photochemotherapy chemistry Carcinoma Basal Cell Lotion Emulsions Female Neoplasm Recurrence Local business |
| Zdroj: | Dermatology. 197:248-254 |
| ISSN: | 1421-9832 1018-8665 |
| DOI: | 10.1159/000018006 |
| Popis: | Background: Photodynamic therapy (PDT) of superficial basal cell carcinomas using endogenous protoporphyrin IX generated by topically applied 5-aminolevulinic acid (5-ALA) is an innovative and clinically encouraging approach. Objective: This paper reports on the first results of an ongoing clinical study on photodynamic therapy of 55 basal cell carcinomas in 19 patients. Methods: Because of the chemical instability of 5-ALA, a novel nanocolloid lotion was developed. This formulation was applied to the lesions under occlusive dressing 6 h before irradiation with visible light from an unfiltered halogen lamp. Light-induced fluorescence was used to ascertain the superficial extension of the tumors. The response to the therapy was assessed by visual inspection and in 13 patients also by biopsies. Results: After a single treatment, 47 (85%) basal cell carcinomas showed a complete response at a follow-up time of at least 6 months. For the remaining 8 (15%) lesions, a partial response was observed, indicated by a marked reduction of the tumor size. The treatment modality without local anesthetics was well tolerated by all patients, with only slight discomfort during light irradiation. Conclusion: Our results indicate that 5-ALA-PDT with our novel formulation, a nanocolloid lotion, is a highly effective and convenient therapy for the treatment of superficial basal cell carcionomas. Its use in the treatment of nodular tumors needs further investigations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|