Direct Intracochlear Acoustic Stimulation Using a PZT Microactuator

Autor: Elizabeth C. Oesterle, Carol A. Robbins, Chuan Luo, Clifford R. Hume, I. Y. Shen, Irina Omelchenko, Robert D. Manson, Guozhong Cao
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Hearing aid
medicine.medical_specialty
Computer science
medicine.medical_treatment
PZT
electroacoustic
cochlea
Guinea Pigs
Stimulation
Audiology
hearing aid
Prosthesis Design
behavioral disciplines and activities
Sensitivity and Specificity
03 medical and health sciences
Speech and Hearing
Microactuator
Random Allocation
0302 clinical medicine
Cochlear implant
medicine
otorhinolaryngologic diseases
Evoked Potentials
Auditory
Brain Stem
Animals
Piezosurgery
030223 otorhinolaryngology
Cochlear implantation
Cochlea
hybrid
Auditory Threshold
Original Articles
lcsh:Otorhinolaryngology
Perilymph
lcsh:RF1-547
Cochlear Implantation
Disease Models
Animal
Cochlear Implants
Otorhinolaryngology
Acoustic Stimulation
Female
sense organs
piezoelectric
perilymph
psychological phenomena and processes
030217 neurology & neurosurgery
Zdroj: Trends in Hearing
Trends in Hearing, Vol 19 (2015)
ISSN: 2331-2165
Popis: Combined electric and acoustic stimulation has proven to be an effective strategy to improve hearing in some cochlear implant users. We describe an acoustic microactuator to directly deliver stimuli to the perilymph in the scala tympani. The 800 µm by 800 µm actuator has a silicon diaphragm driven by a piezoelectric thin film (e.g., lead-zirconium-titanium oxide or PZT). This device could also be used as a component of a bimodal acoustic-electric electrode array. In the current study, we established a guinea pig model to test the actuator for its ability to deliver auditory signals to the cochlea in vivo. The actuator was placed through the round window of the cochlea. Auditory brainstem response (ABR) thresholds, peak latencies, and amplitude growth were calculated for an ear canal speaker versus the intracochlear actuator for tone burst stimuli at 4, 8, 16, and 24 kHz. An ABR was obtained after removal of the probe to assess loss of hearing related to the procedure. In some animals, the temporal bone was harvested for histologic analysis of cochlear damage. We show that the device is capable of stimulating ABRs in vivo with latencies and growth functions comparable to stimulation in the ear canal. Further experiments will be necessary to evaluate the efficiency and safety of this modality in long-term auditory stimulation and its ability to be integrated with conventional cochlear implant arrays.
Databáze: OpenAIRE
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