Ambient and controlled exposures to particulate air pollution and acute changes in heart rate variability and repolarization
| Autor: | Josef Cyrys, Mark W. Frampton, Cathleen Kane, Jelani Wiltshire, Mark J. Utell, Susanne Breitner, Philip K. Hopke, Regina Hampel, Annette Peters, David Oakes, Alexandra Schneider, David Q. Rich, Wojciech Zareba |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty New York lcsh:Medicine Article Standard deviation 03 medical and health sciences 0302 clinical medicine Air pollutants Heart Rate Air Pollution Germany Internal medicine Heart rate Ultrafine particle medicine Humans Heart rate variability Repolarization Computer Simulation Myocardial infarction Particle Size lcsh:Science Air Pollutants Multidisciplinary business.industry lcsh:R Middle Aged medicine.disease Confidence interval 030104 developmental biology 13. Climate action Cardiology Female Particulate Matter lcsh:Q Factor Analysis Statistical business 030217 neurology & neurosurgery |
| Zdroj: | Sci. Rep. 9:1946 (2019) Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) Scientific Reports |
| Popis: | Previous studies have reported increased risks of myocardial infarction in association with elevated ambient particulate matter (PM) in the previous hour(s). However, whether PM can trigger mechanisms that act on this time scale is still unclear. We hypothesized that increases in PM are associated with rapid changes in measures of heart rate variability and repolarization. We used data from panel studies in Augsburg, Germany, and Rochester, New York, USA, and two controlled human exposure studies in Rochester. Data included ECG recordings from all four studies, controlled exposures to (concentrated) ultrafine particles (UFP; particles with an aerodynamic diameter 2.5, aerodynamic diameter 2.5 concentrations in the preceding six hours in both panel studies. We did not find consistent associations between particle metrics and T-wave complexity. This study provided consistent evidence that recent exposures to UFP and PM2.5 can induce acute pathophysiological responses. |
| Databáze: | OpenAIRE |
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