Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry
| Autor: | Xiang Zhang, Hsiao-Hsien Leon Hsu, Kecia N. Carroll, Robert O. Wright, Allan C. Just, Li Zhang, Brent A. Coull, Rosalind J. Wright, Andrea A. Baccarelli, Itai Kloog, Kelly J. Brunst |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nonsynonymous substitution
Mitochondrial DNA Offspring Mitochondrion DNA Mitochondrial Article Pregnancy medicine Humans Molecular Biology Gene Maternal-Fetal Exchange Genetics Air Pollutants biology ATP synthase Racial Groups NADH dehydrogenase Cell Biology medicine.disease Mitochondria Prenatal Exposure Delayed Effects Mutation biology.protein Molecular Medicine Female Particulate Matter |
| Zdroj: | Mitochondrion |
| Popis: | Prenatal ambient particulate matter (PM2.5) exposure impacts infant development and alters placental mitochondrial DNA abundance. We investigated whether the timing of PM2.5 exposure predicts placental mitochondrial mutational load using NextGen sequencing in 283 multi-ethnic mother-infant dyads. We observed increased PM2.5 exposure, particularly during mid- to late- pregnancy and among genes coding for NADH dehydrogenase and subunits of ATP synthase, was associated with a greater amount of nonsynonymous mutations. The strongest associations were observed for participants of African ancestry. Further work is needed to tease out the role of mitochondrial genetics and its impact on offspring development and emerging disease disparities. |
| Databáze: | OpenAIRE |
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