Isoform-Specific Regulation of Na+,K+-ATPase Endocytosis and Recruitment to the Plasma Membrane
| Autor: | Vera Lucas Teixeira, Carlos H. Pedemonte, Alejandro M. Bertorello, Adrian I. Katz |
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| Rok vydání: | 2003 |
| Předmět: |
Neurons
Cell signaling Endosome General Neuroscience Cell Membrane Receptors Cell Surface Receptor-mediated endocytosis Biology Endocytosis Hormones General Biochemistry Genetics and Molecular Biology Cell biology Isoenzymes Cell membrane medicine.anatomical_structure History and Philosophy of Science medicine Animals Homeostasis Plasma membrane Ca2+ ATPase Sodium-Potassium-Exchanging ATPase Na+/K+-ATPase Intracellular |
| Zdroj: | Annals of the New York Academy of Sciences. 986:587-594 |
| ISSN: | 1749-6632 0077-8923 |
| Popis: | The Na(+),K(+)-ATPase traffics between the plasma membrane and intracellular compartments in response to acute changes in membrane receptor activation. These effects are accomplished by a time-dependent interaction of the Na(+),K(+)-ATPase alpha-subunit with specific intracellular signaling molecules either at the plasma membrane (endocytosis) or at the endosome's membranes (recruitment). Most of these studies have been performed in rat renal epithelial cells in which only the alpha(1) isoenzyme is present. Studies in neurons from the neostriatum in which all three alpha-subunit isoforms are present indicate that neurotransmitter-dependent regulation of Na(+),K(+)-ATPase activity displays isoform specificity and also suggest a more complex organization of the intracellular signaling networks controlling Na(+),K(+)-ATPase traffic in mammalian cells. |
| Databáze: | OpenAIRE |
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