Specificity of the Immune Response to a Modified Group B Meningococcal Polysaccharide Conjugate Vaccine
| Autor: | Samuel L. Moore, Esmé K. Farley, Francis Michon, Peter C. Fusco |
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| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
Clinical Biochemistry Immunology Neisseria meningitidis Polysaccharide medicine.disease_cause Group B Microbiology Mice Immune system Non-competitive inhibition Antigen Antibody Specificity medicine Animals Immunology and Allergy chemistry.chemical_classification Antigens Bacterial Vaccines Conjugate biology Polysaccharides Bacterial Vaccine Research Antibodies Bacterial Virology In vitro chemistry biology.protein Antibody |
| Zdroj: | Clinical and Vaccine Immunology. 14:106-109 |
| ISSN: | 1556-679X 1556-6811 |
| Popis: | Antibodies to a modified group B meningococcal polysaccharide vaccine were examined for antigenic and functional specificities. Bactericidal determinants were investigated by using immunoaffinity columns and competitive inhibition of bactericidal activity in an in vitro killing assay. We conclude that nearly all of the vaccine-induced bactericidal activity is specific for the native polysaccharide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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