Exosomal Del-1 as a Potent Diagnostic Marker for Breast Cancer: Prospective Cohort Study
| Autor: | Yee Soo Chae, Pyong-Gon Moon, Moon-Chang Baek, Ho Yong Park, Jeeyeon Lee, Soo Jung Lee, Jin Hyang Jung |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Adult Cancer Research medicine.medical_specialty Early Relapse Breast Neoplasms Enzyme-Linked Immunosorbent Assay 03 medical and health sciences 0302 clinical medicine Breast cancer Risk Factors Internal medicine medicine Biomarkers Tumor Diagnostic biomarker Humans Prospective Studies Prospective cohort study Neoplasm Staging Optimal sampling business.industry Calcium-Binding Proteins Diagnostic marker Middle Aged medicine.disease Prognosis 030104 developmental biology 030220 oncology & carcinogenesis Cohort Biomarker (medicine) Female Neoplasm Grading business Cell Adhesion Molecules |
| Zdroj: | Clinical breast cancer. 21(6) |
| ISSN: | 1938-0666 |
| Popis: | The differential diagnostic role of plasma developmental endothelial locus-1 (Del-1) was proposed in our previous study. Therefore the current study aimed to confirm the diagnostic role and explore the prognostic role of exosomal Del-1 in a prospective cohort of female patients with breast cancer.To determine the optimal sampling time for the postoperative Del-1 measurements, blood was serially collected on days 1, 3, 5, and 7 after surgery in 22 patients (cohort 1). Thereafter, 111 female patients with breast cancer were prospectively enrolled (cohort 2) to compare exosomal Del-1 levels before and after surgery.Among the subsequent prospective cohort, 107 patients (96.4%) showed a high exosomal Del-1 level (optical density [OD] value0.5) at the time of diagnosis. Of these patients, 101 (94.6%) in this high-level group showed normalized Del-1 levels postoperatively, representing a significant difference (mean OD value, 1.232 vs. 0.196; P.00001). High postoperative Del-1 level was significantly associated with a worse disease-free survival adjusted to the clinicopathological characteristics (hazard ratio, 24.0; P = .0011).This study confirmed the normalization of exosomal Del-1 after surgery, indicating exosomal Del-1 as a potent diagnostic biomarker for breast cancer. In addition, because a high Del-1 level after surgery was associated with early relapse, this suggests exosomal Del-1 as a potential prognostic marker by identifying the existence of residual cancer. |
| Databáze: | OpenAIRE |
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