Liver p53 expression in patients with HCV-related chronic hepatitis
| Autor: | Patrizia Gazzerro, Michele Cioffi, Concetta Tuccillo, Anna Maria Molinari, Carmela Loguercio, Antonio Cuomo, C. Del Vecchio Blanco |
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| Přispěvatelé: | Loguercio, Carmelina, Cuomo, A, Tuccillo, C, Gazzerro, P, Cioffi, Michele, Molinari, Anna Maria, DEL VECCHIO BLANCO, C. |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Gene Expression Regulation Viral Male medicine.medical_specialty Cirrhosis Adolescent Hepatitis C virus Hepacivirus Biology medicine.disease_cause Sensitivity and Specificity Gastroenterology Statistics Nonparametric Cohort Studies Liver disease Reference Values Proto-Oncogene Proteins Virology Internal medicine medicine Humans Genetic Predisposition to Disease Probability Analysis of Variance Chi-Square Distribution Hepatology Oncogene Vitamin C Reverse Transcriptase Polymerase Chain Reaction Biopsy Needle Case-control study Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Immunohistochemistry Infectious Diseases Case-Control Studies Hepatocellular carcinoma DNA Viral Immunology Female Tumor Suppressor Protein p53 |
| Zdroj: | Journal of Viral Hepatitis. 10:266-270 |
| ISSN: | 1365-2893 1352-0504 |
| DOI: | 10.1046/j.1365-2893.2003.00432.x |
| Popis: | Mutated p53 acts as a dominant oncogene and alterations in the p53 gene are described in a large number of patients with hepatocellular carcinoma (HCC). It has been demonstrated that hepatitis C virus (HCV)-core protein regulates transcriptionally cellular genes, as well as cell growth and apoptosis. This study was undertaken to evaluate whether p53 may be expressed also in a precocious stage of HCV-related liver damage. We studied p53 expression by immunoluminometric assay on liver samples from 40 patients (M/F 18/ 22, median age 44 years, range 13-64 years) with biopsy-proven HCV-related chronic hepatitis. We considered the following factors: degree of liver damage, liver iron content and HCV-RNA titre. We also evaluated as possible co-factors alcohol and food intake in the last 3 years. p53 was over-expressed in seven of 40 (17.5%) patients. Liver histology documented the presence of unexpected cirrhosis in two patients among the p53 positive subjects. The p53 positive group had a daily ethanol intake significantly higher in respect to that of the p53 negative group (P < 0.05). Alimentary history documented that patients with a p53 over-expression had a lower intake of total calories, monounsaturated fatty acids, vitamin C and riboflavin. Data indicate that p53 over-expression can occur even in initial stages of HCV-related liver disease. |
| Databáze: | OpenAIRE |
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