Risk factors for first-ever acute ischemic non-embolic stroke in elderly individuals
| Autor: | Moses Elisaf, Haralampos J. Milionis, Evangelos Liberopoulos, K. Seferiadis, Eleni Bairaktari, John A. Goudevenos |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Population Hyperlipidemias Brain Ischemia Risk Factors Internal medicine Diabetes mellitus medicine Humans Risk factor education Stroke Aged Retrospective Studies Aged 80 and over education.field_of_study Greece business.industry Cerebral infarction Incidence Smoking Fibrinogen Odds ratio medicine.disease Uric Acid Surgery Cholesterol Case-Control Studies Acute Disease Female Metabolic syndrome Cardiology and Cardiovascular Medicine business Dyslipidemia |
| Zdroj: | International Journal of Cardiology. 99:269-275 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2004.01.013 |
| Popis: | Background: Stroke is a leading cause of mortality and subsequent serious long-term physical and mental disability among survivors. In the elderly, ischemic stroke accounts for more than 80% of all strokes. Objectives: To identify major risk factors for a first-ever acute ischemic/non-embolic stroke in individuals older than 70 years. Methods: A population-based case-control study of patients admitted to the University Hospital of Ioannina, Epirus, Greece, due to first-ever ischemic/non-embolic stroke from March 1997 to January 2002. All patients were subjected to brain CT and had their serum lipids and biochemical metabolic parameters determined within 24 h from the onset of symptoms. Results: A total of 163 (aged>70 years) consecutive stroke patients and 166 apparently healthy volunteers were studied. An atherogenic lipid profile and metabolic disturbances were more prevalent in the patient group than in stroke-free controls. Multivariate logistic regression analysis identified diabetes mellitus (odds ratio (OR), 1.92; 95% CI, 1.02–3.63), triglycerides (TG) (OR, 1.16; 95% CI, 1.09–1.22), HDL-cholesterol (OR, 0.57; 95% CI, 0.43–0.76), apo A–I (OR, 0.80; 95% CI, 0.70–0.92), lipoprotein(a) [LP(a)] (OR, 1.51; 95% CI, 1.25–1.79), uric acid (OR, 1.30; 95% CI, 1.06–1.59) albumin (OR, 0.38; 95% CI, 0.20–0.70) fibrinogen (OR, 1.10; 95% CI, 1.05–1.13) and the metabolic syndrome (OR 2.48, 95% CI, 1.16–5.29) as significantly associated with ischemic/non-embolic stroke. Conclusion: Ischemic non-embolic stroke in the elderly is associated with dyslipidemia and several predictor metabolic factors, which could be substantially modified by lifestyle changes and therapeutic intervention. |
| Databáze: | OpenAIRE |
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