Arene cis-dihydrodiols: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC)
| Autor: | Claire L. Arthurs, Natasha S. Wind, Roger C. Whitehead, Ian J. Stratford, James Raftery, Helen L. Whitby |
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| Rok vydání: | 2007 |
| Předmět: |
Models
Molecular Magnetic Resonance Spectroscopy Cyclohexanones Stereochemistry Metabolite Organic Chemistry Clinical Biochemistry Diastereomer Pharmaceutical Science Antineoplastic Agents Crystallography X-Ray Biochemistry Chemical synthesis chemistry.chemical_compound chemistry Drug Discovery Molecular Medicine Baylis–Hillman reaction Triol Epimer Enantiomer Molecular Biology Enone |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 17:5974-5977 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2007.07.070 |
| Popis: | The synthesis of 6-epi-COTC, a diastereoisomer of Streptomyces metabolite 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC), is described. The anti-cancer activities of the novel analogue, in racemic and enantiomerically pure forms, are presented. |
| Databáze: | OpenAIRE |
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