Stochastic processes constrain the within and between host evolution of influenza virus
| Autor: | Adam S. Lauring, Ryan E. Malosh, Emily T. Martin, Arnold S. Monto, Robert J. Woods, John T. McCrone |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Nonsynonymous substitution bottleneck QH301-705.5 Science 030106 microbiology Genomics Biology Genome Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Virus influenza virus diversity Evolution Molecular 03 medical and health sciences Influenza Human evolution Humans Point Mutation Selection Genetic Biology (General) Evolutionary dynamics Stochastic Processes Microbiology and Infectious Disease General Immunology and Microbiology Stochastic process General Neuroscience transmission General Medicine Sequence Analysis DNA Orthomyxoviridae 030104 developmental biology Genomics and Evolutionary Biology Evolutionary biology Infectious disease (medical specialty) Cohort Medicine Research Article |
| Zdroj: | eLife, Vol 7 (2018) eLife |
| Popis: | The evolutionary dynamics of influenza virus ultimately derive from processes that take place within and between infected individuals. Here we define influenza virus dynamics in human hosts through sequencing of 249 specimens from 200 individuals collected over 6290 person-seasons of observation. Because these viruses were collected from individuals in a prospective community-based cohort, they are broadly representative of natural infections with seasonal viruses. Consistent with a neutral model of evolution, sequence data from 49 serially sampled individuals illustrated the dynamic turnover of synonymous and nonsynonymous single nucleotide variants and provided little evidence for positive selection of antigenic variants. We also identified 43 genetically-validated transmission pairs in this cohort. Maximum likelihood optimization of multiple transmission models estimated an effective transmission bottleneck of 1–2 genomes. Our data suggest that positive selection is inefficient at the level of the individual host and that stochastic processes dominate the host-level evolution of influenza viruses. |
| Databáze: | OpenAIRE |
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