ISAC multiplex testing – results of examination in 100 patients suffering from atopic dermatitis
| Autor: | Jan Krejsek, Irena Krčmová, Josef Bukac, Jarmila Čelakovská, R. Vaňková, Ctirad Andrýs |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty Immunology 01 natural sciences 0404 agricultural biotechnology underlying probability of sensitization Medicine In patient Multiplex lcsh:Agriculture (General) Sensitization Asthma severity of atopic dermatitis allergic rhinitis atopic dermatitis business.industry 010401 analytical chemistry asthma bronchiale 04 agricultural and veterinary sciences Atopic dermatitis medicine.disease 040401 food science Dermatology molecular components lcsh:S1-972 0104 chemical sciences body regions medicine.anatomical_structure business lcsh:RC581-607 Agronomy and Crop Science Food Science |
| Zdroj: | Food and Agricultural Immunology, Vol 31, Iss 1, Pp 1014-1035 (2020) |
| ISSN: | 1465-3443 0954-0105 |
| Popis: | To find the molecular components with the highest underlying probability of sensitization in patients suffering from atopic dermatitis and in subgroup of patients with allergic rhinitis, asthma bronchiale and to determine whether there is some difference of sensitization in mild, moderate and severe form of AD, in patients suffering from asthma bronchiale and allergic rhinitis. The complete dermatological and allergological examination including the examination of the sensitization to molecular allergens with Multiplex ISAC testing was performed. Altogether 100 atopic dermatitis patients were examined – 48 men, 52 women, the average age 40.9 years; the sensitization to molecular components was confirmed in 93% of patients. The highest observed sensitization rate was 61.0% to grass specific molecule Phl p 1, the second most frequent sensitization was 57.0% to Betulaceae-specific molecule Bet v 1. Frequently observed sensitizations were those to PR-10 proteins, NPC2 proteins family, Uteroglobin and Lipocalin. In severe form of atopic dermatitis sensitization to molecular components of NPC2 proteins family, Uteroglobin, Lipocalin and Aspergillus were recorded with a significant higher occurrence. |
| Databáze: | OpenAIRE |
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