Differential expression of fibroblast growth factor receptors by human neurones, astrocytes and microglia
| Autor: | Marco Presta, Lenuta Balaci, Valeria Sogos, Patrizia Dell'Era, G.M. Lauro, F. Gremo, Maria Grazia Ennas |
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| Rok vydání: | 1994 |
| Předmět: |
musculoskeletal diseases
animal structures Fibroblast Growth Factor Biology Axon hillock Fibroblast growth factor Fetus Astrocytes Microglia Neurons Tissue Distribution medicine Humans RNA Messenger Receptor General Neuroscience Blotting Northern Immunohistochemistry Receptors Fibroblast Growth Factor Cell biology medicine.anatomical_structure nervous system Fibroblast growth factor receptor embryonic structures Neuroglia Neuron biological phenomena cell phenomena and immunity Neuroscience Astrocyte |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0959-4965 |
| Popis: | Expression of fibroblast-growth factor receptors (FGFRs) was studied in human fetal neurones, astrocytes and microglia in culture. Northern blot analysis showed that neurones and microglia expressed the mRNAs for FGFR-1, FGFR-2, FGFR-3, FGFR-4 at different levels, whereas astrocytes expressed only FGFR-1 and FGFR-4 mRNAs. Immunocytochemical localization of FGFR-1 revealed that this receptor was predominantly localized on the axon hillock membrane in neurones, and was associated with the plasma membrane of ameboid, activated microglia and of glial-fibrillar acidic protein positive astrocytes. The expression of various members of the FGFR family in all the cell types investigated implicates FGFs in human brain development and functions. |
| Databáze: | OpenAIRE |
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