Too much iron: A masked foe for leukemias
| Autor: | Pierre Brissot, Delphine G. Bernard, Eolia Brissot, Marie-Bérengère Troadec, Olivier Loréal |
|---|---|
| Přispěvatelé: | Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Ineffective erythropoiesis
Iron Overload medicine.medical_treatment Iron Hematopoietic stem cell transplantation [SDV.CAN]Life Sciences [q-bio]/Cancer medicine.disease_cause Iron chelation 03 medical and health sciences 0302 clinical medicine Phlebotomy White blood cell medicine Humans chemistry.chemical_classification Reactive oxygen species Leukemia business.industry Hematopoietic stem cell [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology Hematology medicine.disease 3. Good health Haematopoiesis medicine.anatomical_structure Oncology chemistry Oral chelation 030220 oncology & carcinogenesis Cancer research business Myelodysplastic syndrome 030215 immunology |
| Zdroj: | Blood Reviews Blood Reviews, Elsevier, 2020, 39, pp.100617. ⟨10.1016/j.blre.2019.100617⟩ Blood Reviews, 2020, 39, pp.100617. ⟨10.1016/j.blre.2019.100617⟩ |
| ISSN: | 0268-960X |
| DOI: | 10.1016/j.blre.2019.100617⟩ |
| Popis: | International audience; The role of iron in non-erythroid hematopoietic lineages and its implication in hemato-oncogenesis are still debated. Iron exerts an important role on hematopoietic stem cell transformation and on mature white blood cell differentiation. Iron acts experimentally as an oncogenic cofactor but its exact role in the transformation of the myelodysplastic syndrome into leukemia continues to be discussed. Body iron overload frequently develops mainly as the result of multiple erythrocyte transfusions in patients with leukemia or myelodysplastic syndrome, and, in the latter, as a result of increased ineffective erythropoiesis. Iron overload, especially through the deleterious effects of reactive oxygen species, leads to organ damage that likely impacts the global outcome of patients, especially after hematopoietic stem cell transplantation (HSCT). In these pathological settings (before and after HSCT), oral iron chelation should be considered whenever body iron overload has been firmly established, ideally by magnetic resonance imaging. |
| Databáze: | OpenAIRE |
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