Clinical profile and outcome of early surgery in neonatal-onset glaucoma presenting over a 5-year period
| Autor: | Mini P Singh, Atul Arora, Deepika Dhingra, Sushmita Kaushik, Gunjan Joshi, Gaurav Gupta, Surinder Singh Pandav, Sagarika Snehi, Savleen Kaur |
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| Rok vydání: | 2020 |
| Předmět: |
Intraocular pressure
Pediatrics medicine.medical_specialty genetic structures medicine.medical_treatment Glaucoma Trabeculectomy Neonatal onset Cohort Studies 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine medicine Glaucoma surgery Humans Prospective Studies 030212 general & internal medicine Intraocular Pressure Retrospective Studies Congenital rubella syndrome business.industry Incidence (epidemiology) Infant Newborn Infant medicine.disease eye diseases Sensory Systems Ophthalmology Treatment Outcome Cohort 030221 ophthalmology & optometry business Follow-Up Studies Cohort study |
| Zdroj: | British Journal of Ophthalmology. 106:368-375 |
| ISSN: | 1468-2079 0007-1161 |
| DOI: | 10.1136/bjophthalmol-2020-317230 |
| Popis: | BackgroundNeonatal-onset glaucoma (NOG) is a severe form of childhood glaucoma and is not always due to primary congenital glaucoma (PCG). Due to advances in neonatal care, the incidence of NOG is rising, but it remains an under-reported entity. The objective of the paper was to study the clinical profiles, surgical and visual outcomes of NOG at least 1 year following early surgery.MethodsProspective interventional cohort study at a tertiary care referral centre. Babies with NOG, who presented between January 2013 and December 2017, had a history suggestive of disease onset within 1 month of birth, and underwent surgery by 3 months of age, were prospectively enrolled. Those who completed a 1-year follow-up after surgery were analysed.Results94 eyes of 53 babies were analysed. 35 (66%) had PCG. Neonatal congenital ectropion uveae, congenital rubella syndrome, Peter’s anomaly and Sturge-Weber syndrome comprised the non-PCG group. The mean age at presentation and surgery was 24.8±21.9, and 36.7±29.9 days. Additional glaucoma surgery was required in 43 of the 94 eyes (45.7%). PCG had significantly better outcomes than other glaucomas at all time points. 28.3% of eyes had good vision (LogMar (0–0.5)), 34.7% had moderate visual impairment (LogMar 0.7–1.0) and 16% were blind (LogMar ConclusionOur study shows that NOG does not always have a dismal prognosis. A small but significant proportion could have other underlying conditions than PCG. Timely surgery and rigorous amblyopia therapy resulted in good outcomes in terms of intraocular pressure control and vision in this cohort. |
| Databáze: | OpenAIRE |
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