Decreased Serum Glutamate Levels in Male Adults with Internet Gaming Disorder: A Pilot Study
| Autor: | Sol Hee Bang, Soo-Hyun Paik, Su Min Kwak, Dai Jin Kim, Mi Ran Choi |
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| Rok vydání: | 2017 |
| Předmět: |
Serum
medicine.medical_specialty media_common.quotation_subject Dopamine Neurotransmission Immunoglobulin D 03 medical and health sciences Behavioral Neuroscience Glutamatergic Internet gaming disorder 0302 clinical medicine Glutamates Internal medicine Medicine Pharmacology (medical) media_common biology business.industry Addiction Dopaminergic Glutamate receptor Pathophysiology 030227 psychiatry Psychiatry and Mental health Endocrinology biology.protein Original Article business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Clinical Psychopharmacology and Neuroscience |
| ISSN: | 1738-1088 |
| Popis: | Objective Alteration in glutamatergic neurotransmission and dopaminergic dysfunction has been implicated in both the initiation and expression of addiction related behaviors. This pilot study was aimed to investigate the serum levels of glutamate and dopamine in adults with internet gaming disorder (IGD). Methods We measured serum levels of glutamate and dopamine in male participants with IGD (n=26) and age-matched healthy controls (n=25). Clinical interviews were performed to identify IGD and to rule out psychiatric comorbidities. Serum levels of glutamate and dopamine were examined by enzyme immunoassays using ELISA Kits. Results Serum levels of glutamate were lower among IGD than control (IGD: 24.184±12.303 μg/ml; control: 33.676±12.413 μg/ml; t=2.742, p=0.008), while levels of dopamine did not differ between. Serum glutamate and dopamine levels did not correlate with gaming hours and exposure to game in the IGD group. But serum glutamate levels were positively correlated with the dopamine levels (r=0.360, p=0.013). Conclusion Our results suggest that altered glutamatergic neurotransmission may contribute to the pathophysiology of IGD. |
| Databáze: | OpenAIRE |
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