Acute Eosinophilic Pneumonia Caused by CalciumStearate, an Additive Agent for an Oral Antihistaminic Medication
| Autor: | Jun Kurai, Haruhiko Makino, Yutaka Hitsuda, Hirokazu Touge, Masanari Watanabe, Masanori Miyata, Masahiro Kodani, Takanori Sako, Hiroki Chikumi, Eiji Shimizu |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Drug medicine.medical_specialty media_common.quotation_subject government.form_of_government Administration Oral Gastroenterology Homochlorcyclizine Internal medicine Eosinophilia Internal Medicine medicine Cyclizine Humans Pulmonary Eosinophilia Aged media_common medicine.diagnostic_test business.industry Pruritus General Medicine Eosinophil medicine.disease medicine.anatomical_structure Bronchoalveolar lavage Acute eosinophilic pneumonia Acute Disease Immunology Histamine H1 Antagonists government Itching medicine.symptom business Infiltration (medical) Stearic Acids Tablets medicine.drug |
| Zdroj: | Internal Medicine. 45:1011-1016 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.45.1674 |
| Popis: | A 70-year-old man was admitted to our hospital because of dyspnea after taking an antihistaminic agent (homochlorcyclizine hydrochloride) for itching. Chest roentgenogram showed infiltration in the left lung field, and laboratory data revealed eosinophilia. Examination of the bronchoalveolar lavage fluid revealed an increased eosinophil count. A drug lymphocyte stimulation test was positive only for calcium stearate, an additive contained in the homochlorcyclizine hydrochloride tablet. The pulmonary infiltration and clinical symptoms subsided after withdrawal of all drugs and initiation of glucocorticoid therapy. Therefore, we concluded that this patient's pulmonary disease was caused by calcium stearate, an additive for an antihistaminic drug. An allergic reaction to a drug's additive material should be considered as a rare cause of drug-induced acute eosinophilic pneumonia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|