Immune status, and not HIV infection or exposure, drives the development of the oral microbiota
| Autor: | M. O. Coker, Emmanuel F. Mongodin, L. Hittle, Austin I Omoigberale, P. Akhigbe, Manhattan Charurat, William A. Blattner, Patricia Langenberg, C. Enwonwu, O. Obuekwe, Samer S. El-Kamary |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Male Saliva 030106 microbiology Human immunodeficiency virus (HIV) lcsh:Medicine HIV Infections Dental Caries medicine.disease_cause Paediatric research Microbiology Article 03 medical and health sciences Oral Microbiota Immunocompromised Host Oral and maxillofacial pathology Medicine Humans lcsh:Science Child Immune status Multidisciplinary Perinatal Exposure Molecular medicine business.industry lcsh:R medicine.disease Computational biology and bioinformatics stomatognathic diseases 030104 developmental biology Increased risk Child Preschool Immunology lcsh:Q Female Oral Microbiome business |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Even with antiretroviral therapy, children born to HIV-infected (HI) mothers are at a higher risk of early-life infections and morbidities including dental disease. The increased risk of dental caries in HI children suggest immune-mediated changes in oral bacterial communities, however, the impact of perinatal HIV exposure on the oral microbiota remains unclear. We hypothesized that the oral microbiota of HI and perinatally HIV-exposed-but-uninfected (HEU) children will significantly differ from HIV-unexposed-and-uninfected (HUU) children. Saliva samples from 286 child-participants in Nigeria, aged ≤ 6 years, were analyzed using 16S rRNA gene sequencing. Perinatal HIV infection was significantly associated with community composition (HI vs. HUU—p = 0.04; HEU vs. HUU—p = 0.11) however, immune status had stronger impacts on bacterial profiles (p |
| Databáze: | OpenAIRE |
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