Nonspherical Nanoparticle Shape Stability Is Affected by Complex Manufacturing Aspects: Its Implications for Drug Delivery and Targeting
| Autor: | Daniel Hafner, René Schubel, Julia Engert, Ihsan Amin, Bernard Manuel Haryadi, Rainer Jordan, Gerhard Winter |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Surface Properties Static Electricity Biomedical Engineering Pharmaceutical Science Nanoparticle Nanotechnology particle shape stability 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials Surface tension nonspherical particles Drug Delivery Systems Elastic Modulus Surface roughness Porosity Nanoscopic scale Hydrogen-Ion Concentration morph transformation Silicon Dioxide drug delivery and targeting 021001 nanoscience & nanotechnology Biodegradable polymer 0104 chemical sciences Drug delivery Hydrodynamics Nanoparticles geometries 0210 nano-technology Glass transition Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Advanced Healthcare Materials. 8:1900352 |
| ISSN: | 2192-2659 2192-2640 |
| DOI: | 10.1002/adhm.201900352 |
| Popis: | The shape of nanoparticles is known recently as an important design parameter influencing considerably the fate of nanoparticles with and in biological systems. Several manufacturing techniques to generate nonspherical nanoparticles as well as studies on in vitro and in vivo effects thereof have been described. However, nonspherical nanoparticle shape stability in physiological-related conditions and the impact of formulation parameters on nonspherical nanoparticle resistance still need to be investigated. To address these issues, different nanoparticle fabrication methods using biodegradable polymers are explored to produce nonspherical nanoparticles via the prevailing film-stretching method. In addition, systematic comparisons to other nanoparticle systems prepared by different manufacturing techniques and less biodegradable materials (but still commonly utilized for drug delivery and targeting) are conducted. The study evinces that the strong interplay from multiple nanoparticle properties (i.e., internal structure, Young's modulus, surface roughness, liquefaction temperature [glass transition (Tg) or melting (Tm)], porosity, and surface hydrophobicity) is present. It is not possible to predict the nonsphericity longevity by merely one or two factor(s). The most influential features in preserving the nonsphericity of nanoparticles are existence of internal structure and low surface hydrophobicity (i.e., surface-free energy (SFE) > ���55 mN m���1, material���water interfacial tension 10 nm), porous (>1 m2 g���1), and in possession of low bulk liquefaction temperature ( |
| Databáze: | OpenAIRE |
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