Evaluation of circulating sRAGE in osteoporosis according to BMI, adipokines and fracture risk: a pilot observational study
| Autor: | Carmine Gazzaruso, Emanuela Galliera, Arturo Pujia, Tiziana Montalcini, Pietro Gallotti, M. Marazzi, Massimiliano Marco Corsi Romanelli, Adriana Coppola |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy Aging medicine.medical_specialty Fracture risk Immunology Osteoporosis Adipokine 030209 endocrinology & metabolism lcsh:Geriatrics Bone resorption Bone remodeling 03 medical and health sciences 0302 clinical medicine Glycation end products Glycation Internal medicine Medicine Bone mineral business.industry Leptin Research medicine.disease Osteopenia lcsh:RC952-954.6 030104 developmental biology Endocrinology business lcsh:RC581-607 Circulating RAGE |
| Zdroj: | Immunity & Ageing, Vol 14, Iss 1, Pp 1-12 (2017) Immunity & Ageing : I & A |
| ISSN: | 1742-4933 |
| DOI: | 10.1186/s12979-017-0097-0 |
| Popis: | Background Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone remodelling impairment, at the base of osteoporotic bone fragility, could be related to protein glycation, in association to oxidative stress. The glycation reactions lead to the generation of glycation end products (AGEs) which, in turn, accumulates into bone, where they binds to the receptor for AGE (RAGE). The aim of this study is to investigate the potential role of circulating sRAGE in osteoporosis, in particular evaluating the correlation of sRAGE with the fracture risk, in association with bone mineral density, the fracture risk marker FGF23, and lipid metabolism. Results Circulating level of soluble RAGE correlate with osteopenia and osteoporosis level. Serum sRAGE resulted clearly associated on the one hand to bone fragility and, on the other hand, with BMI and leptin. sRAGE is particularly informative because serum sRAGE is able to provide, as a single marker, information about both the aspects of osteoporotic disease, represented by bone fragility and lipid metabolism. Conclusions The measure serum level of sRAGE could have a potential diagnostic role in the monitoring of osteoporosis progression, in particular in the evaluation of fracture risk, starting from the prevention and screening stage, to the osteopenic level to osteoporosis. |
| Databáze: | OpenAIRE |
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