Effects of beta blockade, PTSD diagnosis, and explicit threat on the extinction and retention of an aversively conditioned response
| Autor: | Scott P. Orr, Linda J. Metzger, Mohammed R. Milad, Natasha B. Lasko, Mark W. Gilbertson, Roger K. Pitman |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Chronic posttraumatic stress disorder Adrenergic beta-Antagonists Conditioning Classical Propranolol Stimulus (physiology) Audiology Fires Extinction Psychological Developmental psychology Stress Disorders Post-Traumatic Heart Rate medicine Humans Habituation Psychophysiologic Aged Veterans Combat Disorders General Neuroscience Memoria Conditioned response Association Learning Retention Psychology Galvanic Skin Response Middle Aged medicine.disease Blockade Neuropsychology and Physiological Psychology Conditioning Arousal Psychology Anxiety disorder medicine.drug |
| Zdroj: | Biological Psychology. 73:262-271 |
| ISSN: | 0301-0511 |
| DOI: | 10.1016/j.biopsycho.2006.05.001 |
| Popis: | An aversively conditioned SC response was assessed in 18 males meeting DSM-IV criteria for chronic posttraumatic stress disorder (PTSD) and 10 trauma-exposed males who never developed PTSD. Effects of beta blockade on acquisition and retention of a conditioned response (CR) were examined by administering propranolol HCl before acquisition or following extinction trials. Retention of the CR was assessed 1 week following acquisition under conditions of non-threat and threat. Conditioned stimuli were colored circles and the unconditioned stimulus (UCS) was a "highly annoying" electrical stimulus. The propranolol failed to produce any measurable effects on acquisition or retention of the CR and there was no evidence of increased conditionability in individuals diagnosed with PTSD. One week following acquisition, the differential CR to the reinforced stimulus was evident only in the threat condition. This suggests that belief in the presence of a threat is necessary and sufficient for activating a previously established CR. |
| Databáze: | OpenAIRE |
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