Trans-[bis(benzimidazol-2-ylidene)dichlorido]platinum(II) complexes with peculiar modes of action and activity against cisplatin-resistant cancer cells

Autor:	Sofia I. Bär, Sebastian W. Schleser, Natalie Oberhuber, Alexander Herrmann, Luca Schlotte, Stefanie E. Weber, Rainer Schobert
Rok vydání:	2022
Předmět:	Inorganic Chemistry Neoplasms Cell Cycle Humans Antineoplastic Agents Cisplatin Biochemistry Platinum
Zdroj:	Journal of inorganic biochemistry. 238
ISSN:	1873-3344
Popis:	Three series of cis- and trans-[bis(benzimidazol-2-ylidene)dichlorido]platinum(II) and cis-[(benzimidazol-2-ylidene)(DMSO)dichlorido]platinum(II) complexes were synthesised and screened for cytotoxicity against six human cancer cell lines. Depending on their N-alkyl and 5-alkoxycarbonyl substituents, two-digit nanomolar to single-digit micromolar IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4695e3b0746d946a26f2276820633c https://pubmed.ncbi.nlm.nih.gov/36274479 Zobrazit plný text záznamu Full Text from ScienceDirect