Somatosensory mismatch negativity in healthy children
| Autor: | Sergio Zanini, Domenico Restuccia, Monica Cazzagon, Giacomo Della Marca, Lucia Martucci, Ivana Del Piero |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Mismatch negativity Contingent Negative Variation Stimulation Audiology Stimulus (physiology) Thumb Somatosensory system Functional Laterality Developmental psychology Discrimination Psychological Child Development Developmental Neuroscience Reference Values Evoked Potentials Somatosensory medicine Humans Child Video game Discrimination (Psychology) Analysis of Variance Brain Awareness Electric Stimulation Contingent negative variation Settore MED/26 - NEUROLOGIA medicine.anatomical_structure Touch Perception Somatosensory evoked potential Pediatrics Perinatology and Child Health Female Neurology (clinical) Psychology |
| Zdroj: | Developmental Medicine & Child Neurology. 51:991-998 |
| ISSN: | 1469-8749 0012-1622 |
| DOI: | 10.1111/j.1469-8749.2009.03367.x |
| Popis: | AIM Event-related potentials (ERPs) obtained when focused attention is kept away from the stimulus (unnoticed stimulation) are possibly linked to automatic mismatch-detection mechanisms, and could be a useful tool to investigate sensory discrimination ability. By considering the high impact of impaired somatosensory integration on many neurological disturbances in children, we aimed to verify whether mismatch-related responses to somatosensory stimulation could be obtained in healthy children. METHOD Eleven healthy participants (age range 6-11y, mean 8y 2mo, SD 1y 7mo; seven males, four females) underwent 'oddball' electrical stimulation of the right hand (80% frequent stimuli delivered to the thumb, 20% deviant stimuli delivered to the fifth finger). Data were compared with those obtained when the frequent stimuli to the thumb were omitted ('standard-omitted' protocol). ERPs were recorded at frontal, central, and parietal scalp locations. Children's overt attention was engaged by a demanding video game. RESULTS In the oddball protocol, deviant stimulation elicited a left central negativity at about 160ms latency, followed by a left frontal negative response at about 220ms latency. Standard-omitted traces showed only a left parietal negative response spreading to right parietal regions. INTERPRETATION Mismatch-related somatosensory responses can be reliably obtained in children, providing that appropriate technical contrivances are used. In clinical use, the frontal components, which are present only during the oddball protocol, could be a reliable and unequivocal neurophysiological marker of the automatic mismatch-detection mechanism. |
| Databáze: | OpenAIRE |
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