Cytogenetic Analysis of the Products of Conception After Spontaneous Abortion in the First Trimester
| Autor: | Yanhua Chen, Zhongyun Li, Jinghui Zhao, Yuanjing Hu, Xueqing Wu, Xueluo Zhang, Jun Wang, Zhijiao Song, Junmei Fan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Aneuploidy Chromosome Disorders Trisomy Abortion Biology Young Adult Monosomy Chromosome 16 Pregnancy Genetics medicine Humans Copy-number variation Molecular Biology Genetics (clinical) Retrospective Studies Chromosome Aberrations Obstetrics Chromosome medicine.disease Triploidy Abortion Spontaneous Pregnancy Trimester First Products of conception Fertilization Cytogenetic Analysis Female Original Article Abnormality Maternal Age |
| Zdroj: | Cytogenet Genome Res |
| ISSN: | 1424-859X 1424-8581 |
| Popis: | In the present study, we retrospectively recruited 340 patients who underwent spontaneous abortions to investigate chromosomal abnormalities of the conception products in the first trimester. We also performed a relevant analysis of clinical factors. Of these patients, 165 had conception products with chromosomal abnormalities, including 135 aneuploidies, 11 triploidies, 10 complex abnormalities, and 9 segmental aneuploidies. The most common abnormal chromosomes were chromosome 16 in the embryo-transfer group and sex chromosomes in the natural-conception group. The most common abnormal chromosomes in all analyzed maternal age groups were sex chromosomes, 16, and 22. The chromosomal abnormality incidence was related to age and number of spontaneous abortions (both p < 0.05), but not to number of pregnancies, deliveries, induced abortions, or methods of conception (all p > 0.05). The rates of abnormality for chromosomes 12, 15, 20, and 22 increased with age, while the rates for chromosomes 6, 7, 13, and X decreased. In all age groups, aneuploidy was by far the most common abnormality; however, the low-incidence distributions of chromosomal abnormalities were entirely different. Overall, chromosomal aneuploidy was the primary cause of pregnancy loss in the first trimester, and low-frequency abnormalities differed across age subgroups. Chromosomal aberrations were found to be related to maternal age and spontaneous abortion, but not all chromosomal abnormalities increased with age. |
| Databáze: | OpenAIRE |
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