| Autor: |
Jeffrey M. Trent, Paul S. Meltzer, FH Thompson, Jørgen Fogh, James T. Casper |
| Rok vydání: |
1985 |
| Předmět: |
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| Zdroj: |
Cancer Genetics and Cytogenetics. 16:189-197 |
| ISSN: |
0165-4608 |
| DOI: |
10.1016/0165-4608(85)90045-7 |
| Popis: |
Chromosome banding analysis was attempted on tumor cells from a total of six rhabdomyosarcomas. Results revealed a variety of chromosome alterations, including frequent structural rearrangement of chromosome #1 and the finding in one patient of multiple double minutes. The single chromosome most consistently involved in structural rearrangements was #3. Simple deletion or translocation of either the long or short arm of chromosome #3 was found in all rhabdomyosarcoma tumors examined in this report. Further, a review of the limited previous literature on rhabdomyosarcoma provided further support for the frequent alteration of chromosome #3 in this disease. Results from our study provide preliminary evidence that alterations of chromosome 3p14–21 may represent a site of nonrandom chromosome change in rhabdomyosarcoma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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