Production and characterization of monoclonal antibodies against the Epstein-Barr virus membrane antigen
| Autor: | T C Schuster, R F Hopkins rd, R Klein, T Witmer, Harvey Rabin, Russell H. Neubauer, Bruce C. Strnad |
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| Rok vydání: | 1982 |
| Předmět: |
Cytotoxicity
Immunologic Herpesvirus 4 Human medicine.drug_class Immunoprecipitation viruses Immunology Monoclonal antibody Antibodies Viral Microbiology Epitope Virus Epitopes Viral Proteins Antigen Antibody Specificity Virology hemic and lymphatic diseases medicine Antigens Viral Glycoproteins biology Antibodies Monoclonal Membrane Proteins Complement System Proteins Primary and secondary antibodies Molecular biology Cytolysis Insect Science biology.protein Antibody Research Article |
| Zdroj: | Journal of virology. 41(1) |
| ISSN: | 0022-538X |
| Popis: | Five murine hybridoma lines that produce monoclonal antibodies against Epstein-Barr virus membrane antigen (MA) were established. Immunoprecipitation experiments demonstrated that three of the antibodies precipitated both the 236,000 (236K) MA and the 212K MA. The other two antibodies precipitated the 86K MA. Antibodies against the 236K-212K MA and the 86K MA mediated complement-dependent cytolysis of Epstein-Barr-virus-infected cells. The antibodies against the 86K MA neutralized both the B95-8 and P3HR-1 viruses. |
| Databáze: | OpenAIRE |
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