Characterization of glucocorticoid receptors in animal lymphoblastic disease: correlation with response to single-agent glucocorticoid treatment
| Autor: | Susan Cotter, Richard Bell, Anne Lillquist, Stephen E. Sallan, Ronald P. McCaffrey |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Receptors
Steroid medicine.medical_specialty Immunology Disease Biology Cat Diseases Biochemistry Chromatography DEAE-Cellulose Dogs Receptors Glucocorticoid Glucocorticoid receptor Prednisone Internal medicine medicine Animals Distribution (pharmacology) Clinical significance Dog Diseases Glucocorticoids CATS Cell Biology Hematology Ligand (biochemistry) Leukemia Lymphoid Endocrinology Cats Glucocorticoid medicine.drug |
| Zdroj: | Blood. 63:380-383 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v63.2.380.380 |
| Popis: | The clinical significance of initial DEAE chromatography of glucocorticoid binders in lymphoblastic disease was evaluated in an animal model. Domestic cats and dogs with lymphoblastic disease were treated with prednisone, 2 mg/kg/day, for 14 days, and the outcome of therapy was correlated with DEAE chromatograms of glucocorticoid binders, using 3H-triamcinolone as ligand. Six of 30 animals had a single-peak low-salt binder species, similar to that seen in a subset of human leukemia, and none of these responded. Of the 29 animals with chromatograms identical to normal tissues, 6 had a complete response and another 11 a partial response. This distribution of responders is statistically significant (p = 0.02). Thus, the leukemia-associated single-peak DEAE species appears to be associated with glucocorticoid resistance, as defined by clinical responsiveness. In contrast, the two- peak normal pattern is a necessary, but insufficient, criterion for defining responsive disease. |
| Databáze: | OpenAIRE |
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