Monodisperse and Uniform Mesoporous Silicate Nanosensitizers Achieve Low-Dose X-Ray-Induced Deep-Penetrating Photodynamic Therapy
| Autor: | Peng Lv, Ying Lv, Tianhang Shi, Hongmin Chen, Wenjing Sun, Yixi Zhuang, Gang Liu, Xiaomei Chen, Xiaoyuan Chen, Jinjie Zhu, Li Luo |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Cell Survival medicine.medical_treatment Dispersity Nanotechnology Photodynamic therapy 02 engineering and technology 010402 general chemistry 01 natural sciences Permeability chemistry.chemical_compound Mice Cell Line Tumor medicine Rose bengal Animals Humans General Materials Science Photosensitizer Fluorescent Dyes Mice Inbred BALB C Rose Bengal Photosensitizing Agents Mechanical Engineering Silicates X-Rays Optical Imaging 021001 nanoscience & nanotechnology Silicate 0104 chemical sciences Radiation therapy chemistry Photochemotherapy Mechanics of Materials Heterografts Nanoparticles 0210 nano-technology Luminescence Oligopeptides Mesoporous silicate |
| Zdroj: | Advanced materials (Deerfield Beach, Fla.). 31(16) |
| ISSN: | 1521-4095 |
| Popis: | X-ray-induced photodynamic therapy (X-PDT) combines both the advantages of radiotherapy (RT) and PDT, and has considerable potential applications in clinical deep-penetrating cancer therapy. However, it is still a major challenge to prepare monodisperse nanoscintillators with uniform size and high light yield. In this study, a general and rapid synthesis method is presented that can achieve large-scale preparation of monodisperse and uniform silicate nanoscintillators. By simply adjusting the metal dopants, silicate nanoscintillators with controllable size and X-ray-excited optical luminescence (450-900 nm) are synthesized by employing a general ion-incorporated silica-templating method. To make full use of external radiation, the silicate nanoscintillators are conjugated with photosensitizer rose bengal and arginylglycylaspartic acid (RGD) peptide, making them intrinsically dual-modal targeted imaging probes. Both in vitro and in vivo experiments demonstrate that the silicate nanosensitizers can accumulate effectively in tumors and achieve significant inhibitory effect on tumor progression under low-dose X-ray irradiation, while minimally affecting normal tissues. The insights gained in this study may provide an attractive route to synthesize nanosensitizers to overcome some of the limitations of RT and PDT in cancer treatment. |
| Databáze: | OpenAIRE |
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