Fate ofMycobacterium tuberculosiswithin Murine Dendritic Cells
| Autor: | Natalya V. Serbina, Kendra A. Bodnar, JoAnne L. Flynn |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Tuberculosis
Lipopolysaccharide T-Lymphocytes Immunology Antigen-Presenting Cells chemical and pharmacologic phenomena Lymphocyte Activation Microbiology Mycobacterium tuberculosis Mice chemistry.chemical_compound Immune system medicine Animals Interferon gamma Antigen-presenting cell Cellular Microbiology: Pathogen-Host Cell Molecular Interactions biology Macrophages Intracellular parasite hemic and immune systems Dendritic Cells Dendritic cell medicine.disease biology.organism_classification Mice Inbred C57BL Infectious Diseases chemistry Cytokines Female Parasitology medicine.drug |
| Zdroj: | Infection and Immunity. 69:800-809 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.69.2.800-809.2001 |
| Popis: | The interaction of microbes with dendritic cells (DCs) is likely to have an enormous impact on the initiation of the immune response against a pathogen. In this study, we compared the interaction ofMycobacterium tuberculosiswith murine bone marrow-derived DCs and macrophages (Mφ) in vitro.M. tuberculosisgrew equally well within nonactivated DCs and Mφ. Activation of DCs and Mφ with gamma interferon and lipopolysaccharide inhibited the growth of the intracellular bacteria in a nitric oxide synthase-dependent fashion. However, while this activation enabled Mφ to kill the intracellular bacteria, theM. tuberculosisbacilli within activated DCs were not killed. Thus, DCs could restrict the growth of the intracellular mycobacteria but were less efficient than Mφ at eliminating the infection. These results may have implications for priming immune responses toM. tuberculosis. In addition, they suggest that DCs may serve as a reservoir forM. tuberculosisin tissues, including the lymph nodes and lungs. |
| Databáze: | OpenAIRE |
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