H2O2 and Engrailed 2 paracrine activity synergize to shape the zebrafish optic tectum
| Autor: | Marion Thauvin, Isabelle Queguiner, Sophie Vriz, Irène Amblard, Christine Rampon, Alain Prochiantz, Vsevolod V. Belousov, Valeriy V. Pak, Alain Joliot, Michel Volovitch |
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| Přispěvatelé: | École des Ponts ParisTech (ENPC), Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Göttingen - Georg-August-Universität Göttingen, Collège de France (CdF (institution)), Gestionnaire, HAL Sorbonne Université 5, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Georg-August-University = Georg-August-Universität Göttingen |
| Rok vydání: | 2020 |
| Předmět: |
inorganic chemicals
0303 health sciences animal structures biology [SDV]Life Sciences [q-bio] Morphogenesis Medicine (miscellaneous) biology.organism_classification General Biochemistry Genetics and Molecular Biology engrailed Cell biology [SDV] Life Sciences [q-bio] 03 medical and health sciences 0302 clinical medicine lcsh:Biology (General) Cell Plasticity Signal transduction General Agricultural and Biological Sciences Tectum lcsh:QH301-705.5 Zebrafish Neural development Developmental biology 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Communications Biology Communications Biology, Nature Publishing Group, 2020, 3 (1), ⟨10.1038/s42003-020-01268-7⟩ Communications Biology, Vol 3, Iss 1, Pp 1-9 (2020) Communications Biology, 2020, 3 (1), ⟨10.1038/s42003-020-01268-7⟩ |
| ISSN: | 2399-3642 |
| Popis: | Although a physiological role for redox signaling is now clearly established, the processes sensitive to redox signaling remains to be identified. Ratiometric probes selective for H2O2 have revealed its complex spatiotemporal dynamics during neural development and adult regeneration and perturbations of H2O2 levels disturb cell plasticity and morphogenesis. Here we ask whether endogenous H2O2 could participate in the patterning of the embryo. We find that perturbations of endogenous H2O2 levels impact on the distribution of the Engrailed homeoprotein, a strong determinant of midbrain patterning. Engrailed 2 is secreted from cells with high H2O2 levels and taken up by cells with low H2O2 levels where it leads to increased H2O2 production, steering the directional spread of the Engrailed gradient. These results illustrate the interplay between protein signaling pathways and metabolic processes during morphogenetic events. |
| Databáze: | OpenAIRE |
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