Serum antinuclear and extractable nuclear antigen antibody prevalence and associated morbidity and mortality in the general population over 15 years
| Autor: | Selmi, C, Ceribelli, A, Generali, E, Scirã, C, Alborghetti, F, Colloredo, G, Porrati, L, Achenza, M, De Santis, M, Cavaciocchi, F, Massarotti, M, Isailovic, N, Paleari, V, INVERNIZZI, PIETRO, Matthias, T, Zucchi, A, Meroni, P., SCIRE', CARLO ALBERTO |
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| Přispěvatelé: | Selmi, C, Ceribelli, A, Generali, E, Scirã, C, Alborghetti, F, Colloredo, G, Porrati, L, Achenza, M, De Santis, M, Cavaciocchi, F, Massarotti, M, Isailovic, N, Paleari, V, Invernizzi, P, Matthias, T, Zucchi, A, Meroni, P, Scire', C |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Survival Immunology Population Autoimmunity Antibodies NO 03 medical and health sciences 0302 clinical medicine Age Age Distribution MED/12 - GASTROENTEROLOGIA Internal medicine Antinuclear medicine Prevalence Immunology and Allergy Humans Clinical significance Nuclear Antigens education Connective Tissue Diseases Connective tissue disease Cancer Clinical epidemiology Gender Antibodies Antinuclear Antigens Nuclear Sex Characteristics 030203 arthritis & rheumatology education.field_of_study business.industry Medicine (all) Hazard ratio Sex Characteristic medicine.disease Titer 030104 developmental biology CTD business Human Sex characteristics |
| Zdroj: | Autoimmunity reviews. 15(2) |
| ISSN: | 1873-0183 |
| Popis: | The prevalence of ANA and anti-ENA in the general population is not well established, especially their clinical significance in healthy subjects. We herein determined the prevalence and predictive value of serum ANA and anti-ENA for connective tissue diseases (CTD), cancer, and mortality. We took advantage of a randomly selected sample of the 1998 general population (Isola I) consisting of 2828 subjects (53% women, age 43 ± 13 years) from a well-defined Northern Italian area. Serum ANA and anti-ENA were tested on the 2690 samples available in 2012 (Isola II, 50% women, age 58 ± 13 years). Administrative databases were searched for CTD, cancer diagnosis, and death cases occurring between enrollment and December 31, 2013. The hazard ratio (HR) was calculated for incident cases. Serum ANA is positive in 18.1% for any titer and 6.1% for titers ≥ 1:160, 23% in subjects over 50 years and 13.1% and 6.1% for any titer and titers ≥ 1:160, respectively, in women. The HR for CTD development was significantly high for all ANA titers, with the highest for ANA ≥ 1:160 (HR 14.19, 95% CI 3.07-65.68). ANA positivity was not associated with cancer (HR 1.03; 95% CI 0.75-1.43), or with mortality (HR adjusted for age and sex 1.40; 95% CI 0.94-2.09). Serum anti-ENA is positive in a minority of subjects with highest figures for anti-nucleosome (1.9%), -histone (1.6%) and -PM/Scl (1.5%). In conclusion, serum ANA prevalence in the general population is highest in senior subjects and in women, while the female predominance is significantly lower compared to overt CTD. Serum ANA is associated with an increased probability of CTD development over time, but does not influence survival or cancer risk. |
| Databáze: | OpenAIRE |
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