Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study
| Autor: | Hye Jin Yoo, Ji A Seo, Yong Gyu Park, Nan Hee Kim, Kyung Mook Choi, Hye Soo Chung, Nam Hoon Kim, Sang Hyun Park, Sei Hyun Baik, Seon Mee Kim, Kyungdo Han, Sin Gon Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Databases Factual lcsh:Medicine 030204 cardiovascular system & hematology Gastroenterology digestive system Article Cohort Studies 03 medical and health sciences Population based cohort Young Adult 0302 clinical medicine Risk Factors Transferases Internal medicine Liver enzyme Republic of Korea medicine Humans 030212 general & internal medicine Myocardial infarction Young adult lcsh:Science Life Style Aged Multidisciplinary business.industry Incidence (epidemiology) Incidence lcsh:R Middle Aged medicine.disease digestive system diseases Quartile Liver Cardiovascular Diseases Cohort Female lcsh:Q business Cohort study |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Although liver enzymes, such as γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), have recently been suggested as risk factors for cardiovascular diseases (CVD), impact on mortality after myocardial infarction (MI) or ischemic stroke (IS) was not previously examined. Using a population-based, nationwide cohort database, we explored the implication of GGT and aminotransferases on the development of CVD and all-cause mortality during a median 9.1 years of follow-up. Among 16,624,006 Korean adults, both GGT and aminotransferases exhibited a positive relationship with MI, IS, and mortality in a multivariate adjusted model. ALT and AST showed U-shaped associations with mortality, whereas GGT showed a positive linear relationship with mortality. The risk of 1-year mortality after MI or IS was significantly higher in the highest quartile of GGT compared to the lowest quartile (HR, 1.46; 95% CI, 1.40-1.52). The implication of GGT on MI, IS, and mortality persisted regardless of traditional cardiovascular risk parameters. This study demonstrated the unique pattern of association of ALT, AST, and GGT with the development of CVD and all-cause mortality in the Korean population. In particular, GGT showed the most robust linear relationship with mortality before and after cardiovascular events independent of risk factors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|