Differential Diagnosis and Workup of Monocytosis: A Systematic Approach to a Common Hematologic Finding

Autor: Abhishek A. Mangaonkar, Aaron J. Tande, Delamo I. Bekele
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Cancer Research
medicine.medical_specialty
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Chronic myelomonocytic leukemia
Monocytes
Chronic Myelomonocytic Leukemia
Clonal Evolution
Diagnosis
Differential
03 medical and health sciences
0302 clinical medicine
Monocytosis
Bone Marrow
medicine
Biomarkers
Tumor
Humans
Medical diagnosis
Intensive care medicine
Non-classical
business.industry
Diagnostic test
Disease Management
Leukemia
Myelomonocytic
Chronic
Hematology
Topical Collection on Myelodysplastic Syndromes and MPN/MDS Overlap (M Patnaik
Section Editor)
medicine.disease
Flow Cytometry
Classical
Oncology
Leukemia
Myeloid
030220 oncology & carcinogenesis
Disease Susceptibility
Differential diagnosis
business
Intermediate
030215 immunology
Zdroj: Current Hematologic Malignancy Reports
ISSN: 1558-822X
1558-8211
Popis: Purpose of Review Monocytosis is a frequently encountered clinical condition that needs appropriate investigation due to a broad range of differential diagnoses. This review is meant to summarize the latest literature in the diagnostic testing and interpretation and offer a stepwise diagnostic approach for a patient presenting with monocytosis. Recent Findings Basic studies have highlighted the phenotypic and functional heterogeneity in the monocyte compartment. Studies, both translational and clinical, have provided insights into why monocytosis occurs and how to distinguish the different etiologies. Flow cytometry studies have illustrated that monocyte repartitioning can distinguish chronic myelomonocytic leukemia, a prototypical neoplasm with monocytosis from other reactive or neoplastic causes. Summary In summary, we provide an algorithmic approach to the diagnosis of a patient presenting with monocytosis and expect this document to serve as a reference guide for clinicians.
Databáze: OpenAIRE
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