Diagnostic accuracy of non-contrast magnetic resonance enterography in detecting active bowel inflammation in pediatric patients with diagnosed or suspected inflammatory bowel disease to determine necessity of gadolinium-based contrast agents
| Autor: | Ting Y. Tao, Jeffrey Teckman, Stacy J Kim, Dhiren Patel, Shannon G. Farmakis, Paula Buchanan, Thomas L Ratchford, Jeffrey J. Brown |
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| Rok vydání: | 2019 |
| Předmět: |
Gadolinium DTPA
Male medicine.medical_specialty Adolescent Contrast Media Fleiss' kappa Sensitivity and Specificity Inflammatory bowel disease Endoscopy Gastrointestinal 030218 nuclear medicine & medical imaging 03 medical and health sciences Meglumine 0302 clinical medicine McNemar's test 030225 pediatrics Biopsy Organometallic Compounds medicine Humans Radiology Nuclear Medicine and imaging Child Retrospective Studies Neuroradiology medicine.diagnostic_test business.industry Retrospective cohort study Inflammatory Bowel Diseases medicine.disease Magnetic Resonance Imaging Endoscopy Pediatrics Perinatology and Child Health Female Histopathology Radiology business |
| Zdroj: | Pediatric Radiology. 49:759-769 |
| ISSN: | 1432-1998 0301-0449 |
| DOI: | 10.1007/s00247-019-04369-6 |
| Popis: | Pediatric patients with inflammatory bowel disease (IBD) are at increased risk of gadolinium deposition given the potential need for multiple contrast-enhanced magnetic resonance enterography (MRE) exams over their lifetime. To determine whether gadolinium-based contrast agents are necessary in assessing active bowel inflammation on MRE in pediatric patients with known or suspected IBD. We conducted a retrospective study of 77 patients (7–18 years; 68.8% male) with known (n=58) or suspected (n=19) IBD and endoscopy with biopsy performed within 30 days of MRE without and with contrast evaluated bowel and non-bowel findings. During three visual analysis sessions, two radiologists reviewed pre-, post-, and pre-/post-contrast MRE images. A third radiologist independently reviewed 27 studies to assess inter-reader reliability. We used Cohen kappa (κ), Fleiss kappa, (κF), McNemar test, and sensitivity and specificity to compare MRE readings to combined endoscopic/histopathological findings (the reference standard). The pre- and pre-/post-contrast-enhanced MRE vs. combined endoscopic/histopathological results had moderate agreement (85.7%; κ 0.713, P |
| Databáze: | OpenAIRE |
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