Evidence for a Locus Regulating Total Serum IgE Levels Mapping to Chromosome 5
| Autor: | Eugene R. Bleecker, PJ Amelung, Dirkje S. Postma, Deborah A. Meyers, Roy C. Levitt, Carolien I.M. Panhuysen, Jianfeng Xu |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Genetic Markers Male Candidate gene Allergy Genetic Linkage Locus (genetics) Immunoglobulin E Gene mapping Genetic linkage Hypersensitivity Genetics medicine Humans Child Netherlands Asthma Genes Immunoglobulin biology Chromosome Mapping medicine.disease Phenotype Immunology biology.protein Chromosomes Human Pair 5 Female Antibody |
| Zdroj: | Genomics. 23:464-470 |
| ISSN: | 0888-7543 |
| DOI: | 10.1006/geno.1994.1524 |
| Popis: | Genetics studies of total serum IgE levels were performed since high IgE levels correlate with clinical expression of allergy and asthma. Families ascertained through a parent with asthma were genotyped for markers on 5q where there are multiple candidate genes that may influence the control of IgE and inflammation. Evidence for linkage of the IgE phenotype to 5q was obtained by both sib-pair and lod score analysis with evidence for recessive inheritance of high IgE levels from segregation analysis. These findings represent a major step in mapping genes important in the regulation of allergic responses and the pathogenesis of asthma. |
| Databáze: | OpenAIRE |
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