Size matters : Grey matter brain reserve predicts executive functioning in the elderly

Autor: Arjen J. C. Slooter, Friedrich Borchers, Florian Lammers, Insa Feinkohl, Tobias Pischon, Simone Kühn, Norman Zacharias, Claudia Spies, Georg Winterer, M. Laubach
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Oncology
Male
medicine.medical_specialty
Cognitive Neuroscience
Trail Making Test
Cognitive reserve
Experimental and Cognitive Psychology
Neuroimaging
Grey matter
050105 experimental psychology
Cohort Studies
03 medical and health sciences
Behavioral Neuroscience
Executive Function
0302 clinical medicine
Atrophy
Elderly
Brain reserve
Neuropsychology
Internal medicine
medicine
Journal Article
Dementia
Humans
0501 psychology and cognitive sciences
Cognitive Dysfunction
Cognitive decline
Gray Matter
Aged
Aged
80 and over
05 social sciences
Brain
Organ Size
medicine.disease
Prognosis
Magnetic Resonance Imaging
medicine.anatomical_structure
Cognitive Aging
Cardiovascular and Metabolic Diseases
Female
Psychology
Function and Dysfunction of the Nervous System
Executive functioning
030217 neurology & neurosurgery
Zdroj: Neuropsychologia
Neuropsychologia, 119, 172. Elsevier Limited
ISSN: 0028-3932
Popis: Preserved executive functioning (EF) is crucial for daily functioning in the elderly and it appears to predict dementia development. We sought to clarify the role of atrophy-corrected cortical grey matter (GM) volume as a potential brain reserve (BR) marker for EF in the elderly. In total, 206 pre-surgical subjects (72.50 ± 4.95 years; mean MMSE score 28.50) were investigated. EF was primarily assessed using the Trail Making Test B (TMT B). Global/ lobar GM volumes were acquired with T1 MP-RAGE. Adjusting for key covariates including a brain atrophy index (i.e. brain parenchymal fraction), multiple linear regression analysis was used to study associations of GM volumes and TMT B. All GM volumes - most notably of global GM - were significantly associated with TMT B independently of GM atrophy (ß = -0.201 to -0.275, p = 0.001 to 0.012). Using atrophy-corrected GM volume as an estimate of maximal GM size in youth may serve as a BR predictor for cognitive decline in future studies investigating BR in the elderly.
Databáze: OpenAIRE
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