Size matters : Grey matter brain reserve predicts executive functioning in the elderly
Autor: | Arjen J. C. Slooter, Friedrich Borchers, Florian Lammers, Insa Feinkohl, Tobias Pischon, Simone Kühn, Norman Zacharias, Claudia Spies, Georg Winterer, M. Laubach |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Oncology
Male medicine.medical_specialty Cognitive Neuroscience Trail Making Test Cognitive reserve Experimental and Cognitive Psychology Neuroimaging Grey matter 050105 experimental psychology Cohort Studies 03 medical and health sciences Behavioral Neuroscience Executive Function 0302 clinical medicine Atrophy Elderly Brain reserve Neuropsychology Internal medicine medicine Journal Article Dementia Humans 0501 psychology and cognitive sciences Cognitive Dysfunction Cognitive decline Gray Matter Aged Aged 80 and over 05 social sciences Brain Organ Size medicine.disease Prognosis Magnetic Resonance Imaging medicine.anatomical_structure Cognitive Aging Cardiovascular and Metabolic Diseases Female Psychology Function and Dysfunction of the Nervous System Executive functioning 030217 neurology & neurosurgery |
Zdroj: | Neuropsychologia Neuropsychologia, 119, 172. Elsevier Limited |
ISSN: | 0028-3932 |
Popis: | Preserved executive functioning (EF) is crucial for daily functioning in the elderly and it appears to predict dementia development. We sought to clarify the role of atrophy-corrected cortical grey matter (GM) volume as a potential brain reserve (BR) marker for EF in the elderly. In total, 206 pre-surgical subjects (72.50 ± 4.95 years; mean MMSE score 28.50) were investigated. EF was primarily assessed using the Trail Making Test B (TMT B). Global/ lobar GM volumes were acquired with T1 MP-RAGE. Adjusting for key covariates including a brain atrophy index (i.e. brain parenchymal fraction), multiple linear regression analysis was used to study associations of GM volumes and TMT B. All GM volumes - most notably of global GM - were significantly associated with TMT B independently of GM atrophy (ß = -0.201 to -0.275, p = 0.001 to 0.012). Using atrophy-corrected GM volume as an estimate of maximal GM size in youth may serve as a BR predictor for cognitive decline in future studies investigating BR in the elderly. |
Databáze: | OpenAIRE |
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