Quantitative bone imaging biomarkers to diagnose temporomandibular joint osteoarthritis

Autor: Lucia H. S. Cevidanes, Pablo Hernandez, Jonas Bianchi, João Roberto Gonçalves, Beatriz Paniagua, Fabiana N. Soki, A.C. de Oliveira Ruellas, Lawrence M Ashman, Jean-Baptiste Vimort, Marilia Yatabe, Marcos Ioshida, Erika Benavides
Přispěvatelé: University of Michigan, Universidade Estadual Paulista (Unesp), Inc.
Rok vydání: 2019
Předmět:
Zdroj: Int J Oral Maxillofac Surg
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 1399-0020
Popis: Made available in DSpace on 2020-12-12T01:29:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Norges Idrettshøgskole Bone degradation of the condylar surface is seen in temporomandibular joint osteoarthritis (TMJ OA); however, the initial changes occur in the subchondral bone. This cross-sectional study was performed to evaluate 23 subchondral bone imaging biomarkers for TMJ OA. The sample consisted of high-resolution cone beam computed tomography scans of 84 subjects, divided into two groups: TMJ OA (45 patients with TMJ OA) and control (39 asymptomatic subjects). Six regions of each mandibular condyle scan were extracted for computation of five bone morphometric and 18 grey-level texture-based variables. The groups were compared using the Mann–Whitney U-test, and the receiver operating characteristics (ROC) curve was determined for each variable that showed a statically significance difference. The results showed statistically significant differences in the subchondral bone microstructure in the lateral and central condylar regions between the control and TMJ OA groups (P < 0.05). The area under the ROC curve (AUC) for these variables was between 0.620 and 0.710. In conclusion, 13 imaging bone biomarkers presented an acceptable diagnostic performance for the diagnosis of TMJ OA, indicating that the texture and geometry of the subchondral bone microarchitecture may be useful for quantitative grading of the disease. Department of Orthodontics and Pediatric Dentistry School of Dentistry University of Michigan Department of Pediatric Dentistry São Paulo State University (Unesp) School of Dentistry Oral and Maxillofacial Surgery Hospital Dentistry University of Michigan Kitware Inc. Department of Periodontics and Oral Medicine School of Dentistry University of Michigan Department of Pediatric Dentistry São Paulo State University (Unesp) School of Dentistry
Databáze: OpenAIRE
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