Effects of Hyperthermia and L-Ascorbic Acid on Glucose, Pyruvate, and Lactate Metabolism in Ehrlich Ascites Carcinoma Cells
| Autor: | G. E. Piontek, Charles A. Cain, J. A. Milner |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
Hyperthermia medicine.medical_specialty Hot Temperature Cellular respiration Ascorbic Acid In Vitro Techniques Biology General Biochemistry Genetics and Molecular Biology Ehrlich ascites carcinoma Mice In vivo Internal medicine Cyclic AMP medicine Animals Neoplasm Carcinoma Ehrlich Tumor Pyruvates Metabolism medicine.disease Ascorbic acid In vitro Glucose Endocrinology Biochemistry Lactates |
| Zdroj: | Experimental Biology and Medicine. 161:597-599 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-161-40604 |
| Popis: | SummaryShort exposure (1 hr) to hyper-thermia (42.5°) is not accompanied by altered cellular respiration in EATC. Ascorbic acid has been shown to significantly effect metabolism in both in vitro and in vivo experiments. Ascorbic acid results in a significant reduction in lactate concentrations in EATC. The present evidence suggest that these alterations in metabolism are not due to alterations in cAMP concentrations. Alterations in the electron transport chain may account for the changes in metabolism observed with ascorbic acid supplementation. Although ascorbic acid does not inhibit or destroy EATC under our conditions, It does lead to significant metabolic changes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|