Modulation of Total IgE Levels in Serum of Normal and Athymic Nude BALB/c Mice by T Cells and Exogenous Antigenic Stimulation
| Autor: | A. Van Oudenaren, Robbert Benner, P.W.C. Soeting, Huub F. J. Savelkoul, T W van den Akker |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Aging
medicine.medical_specialty Ratón T-Lymphocytes medicine.medical_treatment Immunology Dose-Response Relationship Immunologic Mice Nude Immunoglobulin E BALB/c Mice Immune system Antigen Internal medicine medicine Animals Immunology and Allergy Antigens Mice Inbred BALB C biology business.industry General Medicine Thymectomy biology.organism_classification Dose–response relationship Endocrinology Immunoglobulin G biology.protein Antibody business |
| Zdroj: | International Archives of Allergy and Immunology. 89:113-119 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000234933 |
| Popis: | Several different grades of T-system impairment were studied for their effects on the total serum IgE concentration in BALB/c mice. Homozygous athymic nu/nu mice and their heterozygous nu/+ littermates were compared for serum IgE levels while kept under either barrier-maintained or conventional conditions. The results show a paradox between the T-cell dependency of the IgE immune response and the increased levels of serum IgE in the absence of T cells. Both barrier-maintained and conventionalized nu/nu mice have at least two fold increased serum IgE levels as compared to nu/+ mice. With age, IgE levels increased faster and reached higher plateau values in nu/nu than in nu/+ mice. Moreover, after adult thymectomy of BALB/c mice the serum IgE levels increased up to 15-fold at 4 months of age, while infusion of immunocompetent T cells in nude mice resulted in a 2- to 5-fold decrease of the IgE level. |
| Databáze: | OpenAIRE |
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