Evidence of oxidative stress in Schnyder corneal dystrophy
| Autor: | M. Krause, Zisis Gatzioufas, V Kozobolis, F. Schirra, Petar Charalambous, U. Loew, Berthold Seitz |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Nitric Oxide Synthase Type III Nitric Oxide Synthase Type II medicine.disease_cause Nitric oxide Lipid peroxidation Pathogenesis Cellular and Molecular Neuroscience chemistry.chemical_compound Internal medicine medicine Humans Corneal epithelium Corneal Dystrophies Hereditary business.industry Nitrotyrosine Malondialdehyde eye diseases Sensory Systems Surgery Corneal Disorder Ophthalmology Oxidative Stress Endocrinology medicine.anatomical_structure chemistry Case-Control Studies Female sense organs Lipid Peroxidation business Oxidative stress |
| Zdroj: | The British journal of ophthalmology. 94(9) |
| ISSN: | 1468-2079 |
| Popis: | Schnyder corneal dystrophy (SCD) is a rare, autosomal, dominantly inherited corneal disorder affecting the central and peripheral cornea and is characterised by cholesterol and phospholipid deposition in the corneal epithelium and stroma, leading to progressive corneal opacification, which may result in glare and disproportionate loss of photopic vision.1–3 Nitric oxide serves as a mediator in diverse and complex cellular processes throughout the eye.4 Increased production of nitric oxide, however, can lead to cytotoxic effects mediated by peroxynitrate, a potent oxidant that finally forms the stable product nitrotyrosine (NT). NT is considered a specific marker for nitrogen-related oxidants; therefore, its presence provides evidence of oxidative damage.5 Malondialdehyde (MDA) is the end product of free-radical–initiated lipid peroxidation, indicating oxygen-dependent degradation of cholesterol and phospholipids.6 7 In view of this evidence, the aim of our study was to examine the possible contribution of the nitric oxide pathway and lipid peroxidation to the pathogenesis of SCD. We examined three eyes from three patients with SCD who underwent a penetrating keratoplasty (PK) in our department (figure 1). The demographic and clinical data of the patients … |
| Databáze: | OpenAIRE |
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