Ribavirin attenuates the respiratory immune responses to influenza viral infection in mice
| Autor: | Yun Li, Yan-ni Lai, Fengxue Zhang, Ni Liu, Shang-hui Liao, Pei-Ping Xu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
viruses 030106 microbiology Interleukin-1beta Respiratory System Hemagglutinin (influenza) Inflammation Biology Virus Replication Antiviral Agents Virus 03 medical and health sciences chemistry.chemical_compound Interferon-gamma Mice Immune system Influenza A Virus H1N1 Subtype Orthomyxoviridae Infections Virology Ribavirin medicine Animals Lung Interleukin-6 Tumor Necrosis Factor-alpha Antibody titer virus diseases General Medicine biochemical phenomena metabolism and nutrition Toll-Like Receptor 2 Immunoglobulin A Toll-Like Receptor 4 030104 developmental biology medicine.anatomical_structure chemistry Viral replication Immunoglobulin G Immunology biology.protein Female medicine.symptom Respiratory tract |
| Zdroj: | Archives of virology. 162(6) |
| ISSN: | 1432-8798 |
| Popis: | Ribavirin is a broad-spectrum antiviral agent that is used against RNA and DNA viruses and has been reported to inhibit infection by influenza A and B virus in vitro and in vivo. Studies have shown that ribavirin can lower convalescent antibody titers in young children hospitalized with influenza. Here, we report that ribavirin administration in juvenile mice significantly attenuated respiratory immune responses, production of total IgA and hemagglutinin (HA)-specific secretory IgA responses on the mucosal surface. In contrast, systemic IgG and IgA responses were not affected. Ribavirin significantly suppressed toll-like receptor 2 and 4 expression in the lung and decreased the level of IL-1β, IL-6, TNF-α, and IFN-γ in lung tissues of mice infected with influenza virus. Our findings suggest ribavirin appears to be able to inhibit viral replication and, as a result, TLR and cytokine expression are not up-regulated, attenuating inflammation as well as the respiratory tract’s immune response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink