Biomarkers Determining Prognosis of Atrial Fibrillation Ablation
| Autor: | Konstantinos Gatzoulis, Dimitris Tsiachris, Evangelos Oikonomou, Charis Kossyvakis, Spyridon Deftereos, Christodoulos Stefanadis, Gerasimos Siasos, George V. Giannopoulos, Dimitris Tousoulis, Constantinos Tsioufis |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Rhythm control Catheter ablation macromolecular substances 030204 cardiovascular system & hematology Biochemistry Pulmonary vein 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Recurrence Internal medicine Atrial Fibrillation Drug Discovery Secondary Prevention medicine Animals Humans Colchicine 030212 general & internal medicine Natriuretic Peptides Pharmacology business.industry Myocardium Organic Chemistry Atrial fibrillation Prognosis Ablation medicine.disease MicroRNAs Oxidative Stress Treatment Outcome chemistry Persistent atrial fibrillation Catheter Ablation cardiovascular system Cardiology Molecular Medicine Inflammation Mediators business Biomarkers |
| Zdroj: | Current Medicinal Chemistry. 26:925-937 |
| ISSN: | 0929-8673 |
| Popis: | Catheter ablation for rhythm control is recommended in specific patient populations with paroxysmal, persistent, or long-standing persistent atrial fibrillation. Pulmonary vein isolation is the cornerstone of the ablative therapy for atrial fibrillation. However, relapse is still common since the single procedure efficacy of atrial fibrillation ablation was estimated to be 60-80% in paroxysmal and 50-70% in persistent atrial fibrillation. It is important to identify predictors of successful atrial fibrillation patients ablation. In the present review, we will assess the role of available biomarkers to predict responders of an initial atrial fibrillation catheter ablation. Emphasis has been given on the role of myocardial injury biomarkers, natriuretic peptides and traditional inflammatory markers. Novel inflammatory markers, oxidative stress biomarkers and microRNAs have also been examined as predictors of a successful atrial fibrillation procedure. Notably, the impact of procedural and short-term administration of steroids, as well as the role of colchicine on preventing atrial fibrillation recurrence after ablation is thoroughly presented. |
| Databáze: | OpenAIRE |
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