T2* weighted fetal MRI and the correlation with placental dysfunction
| Autor: | Kirstine Baadsgaard, Ditte N. Hansen, David A. Peters, Jens B. Frøkjær, Marianne Sinding, Anne Sørensen |
|---|---|
| Rok vydání: | 2023 |
| Předmět: |
Fetal Growth Retardation
Placenta Diseases Pregnancy High-Risk Fetal growth restriction T2 Obstetrics and Gynecology Gestational Age Magnetic Resonance Imaging Placenta/blood supply Fetal oxygenation Reproductive Medicine Pregnancy Low birth weight Humans Birth Weight Female Transverse relaxation Developmental Biology |
| Zdroj: | Baadsgaard, K, Hansen, D N, Peters, D A, Frøkjær, J B, Sinding, M & Sørensen, A 2023, ' T2* weighted fetal MRI and the correlation with placental dysfunction ', Placenta, vol. 131, pp. 90-97 . https://doi.org/10.1016/j.placenta.2022.12.002 |
| ISSN: | 0143-4004 |
| DOI: | 10.1016/j.placenta.2022.12.002 |
| Popis: | Introduction: Transverse relaxation time (T2*) is related to tissue oxygenation and morphology. We aimed to describe T2* weighted MRI in selected fetal organs in normal pregnancies, and to investigate the correlation between fetal organ T2* and placental T2*, birthweight (BW) deviation, and redistribution of fetal blood flow. Methods: T2*-weighted MRI was performed in 126 singleton pregnancies between 23+6- and 41+3-weeks’ gestation. The T2* value was obtained from the placenta and fetal organs (brain, lungs, heart, liver, kidneys, and spleen). In normal BW pregnancies (BW > 10th centile), the correlation between the T2* value and gestational age (GA) at MRI was estimated by linear regression. The correlation between fetal organ Z-score and BW group was demonstrated by boxplots and investigated by analysis of variance (ANOVA) for each organ. Results: In normal BW pregnancies fetal organ T2* was negatively correlated with GA. We found a significant correlation between BW group and fetal organ T2* z-score in the fetal heart, kidney, lung and spleen. A positive linear correlation was demonstrated between fetal organ T2* and outcomes related to placental function such as BW deviation and placenta T2* in all investigated fetal organs except for the fetal liver. In the fetal heart, kidneys, and spleen the T2* value showed a significant correlation with fetal redistribution of blood flow (Middle cerebral artery Pulsatility Index) before delivery. Discussion: Fetal T2* is correlated with BW, placental function, and redistribution of fetal blood flow, suggesting that fetal organ T2* reflects fetal oxygenation and morphological changes related to placental dysfunction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect